10,148 research outputs found

    Ethical Issues in Fetal Tissue Transplants

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    Development of a Fuzzy Logic Model-Less Aircraft Controller

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    The Modeling and Control for Agile Aircraft Development (MCAAD) group at NASA Langley Research Center(LaRC) is developing techniques for Real-Time Global Modeling (RTGM) and Robust Learning Control (RLC) for NASAā€™s Transformational Tools and Technologies Project. This project seeks to develop a systematic approach to reduce the iterative nature of aircraft design by introducing a model-less control law and enabling inflight aerodynamic modeling and controller design. The development of the flight control system without prior knowledge of the aircraft aerodynamic model makes use of TakagiSugeno-Kang fuzzy logic inference systems for pitch and roll controllers and are tested in various simulations and wind tunnel platforms. These fuzzy logic controllers are not based on a mathematical model but rather on a rule base of generic flight control laws generated from the designerā€™s knowledge of aircraft flight mechanics. The controller architecture uses two channels to provide absolute and incremental controller commands as needed. The absolute channel is designed to reject disturbances and decrease rise time, while the incremental channel provides tracking and reduced steady state error. To provide controllers with acceptable performance without the need for tuning, a general method for selecting input and output scaling gains for the fuzzy inference systems is proposed. A performance and robustness comparison of similarly configured Type-1 and Interval Type-2 fuzzy logic controllers is made. The fuzzy logic controllers were implemented on an aircraft model in the NASA Langley 12-Foot low speed tunnel mounted on a free-to-pitch and free-to-roll rig. The development of the controller architectures and wind tunnel results are presented

    Biophysical drivers of carbon dioxide and methane fluxes in a restored tidal freshwater wetland

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    Wetlands store large amounts of carbon (C) in biomass and soils, playing a crucial role in offsetting greenhouse gas (GHG) emissions; however, they also account for 30% of global yearly CH4 emissions. Anthropogenic disturbance has led to the decline of natural wetlands throughout the United States, with a corresponding increase in created and restored wetlands. Studies characterizing biogeochemical processes in restored forested wetlands, particularly those that are both tidal and freshwater, are lacking but essential for informing science- based carbon management

    Regioselective Reactions of Highly Substituted Arynes

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    The fully regioselective reactivity of four new highly substituted silyl aryl triflate aryne precursors in aryne acyl-alkylation, acyl-alkylation/condensation, and heteroannulation reactions is reported. The application of these more complex arynes provides access to diverse natural product scaffolds and obviates late-stage functionalization of aromatic rings

    Provision of Fluoride Varnish Treatment by Medical and Dental Care Providers: Variation by Race/Ethnicity and Levels of Urban Influence

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    Objective: In 2004, Wisconsin Medicaid policy changed to allow medical care providers to be reimbursed for fluoride varnish treatment (FVT) to children\u27s teeth to improve access and utilization. To date, no study has been published on whether geographic and racial/ethnic variation in the provision of FVT in response to this policy change exists. This study\u27s objective is to examine the association of rates of FVT for children enrolled in Wisconsin Medicaid with race/ethnicity, urban influence codes (UIC), and dental health professional shortage area (DHPSA) designation based on county of residence. Methods: A retrospective, preā€“post design was used based on FVT claims for children in the Wisconsin Medicaid program from 2002 to 2006. Poisson regression models were used to evaluate the association of rates of FVT claims with race/ethnicity, UIC, and DHPSA designation. Results: The rate of FVT claims varied by resident county-type according to UIC and DHPSA designation, age, and race/ethnicity. Post-policy, the largest increases were observed for Native Americans residing in non-DHPSA counties, enrollees living in rural counties, and for Hispanics living in partial and entire DHPSA counties. African-Americans residing in partial DHPSA and metropolitan counties displayed the lowest rates of FVT claims. Conclusions: Overall access and utilization of FVT increased, but substantial racial/ethnic and geographic variation in the provision of FVT for children enrolled in Wisconsin Medicaid was observed. Future policies should incorporate measures that will specifically address the racial and geographic variations identified in this study

    Ventricular Tachycardia in the Absence of Structural Heart Disease

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    In up to 10% of patients who present with ventricular tachycardia (VT), obvious structural heart disease is not identified. In such patients, causes of ventricular arrhythmia include right ventricular outflow tract (RVOT) VT, extrasystoles, idiopathic left ventricular tachycardia (ILVT), idiopathic propranolol-sensitive VT (IPVT), catecholaminergic polymorphic VT (CPVT), Brugada syndrome, and long QT syndrome (LQTS). RVOT VT, ILVT, and IPVT are referred to as idiopathic VT and generally do not have a familial basis. RVOT VT and ILVT are monomorphic, whereas IPVT may be monomorphic or polymorphic. The idiopathic VTs are classified by the ventricle of origin, the response to pharmacologic agents, catecholamine dependence, and the specific morphologic features of the arrhythmia. CPVT, Brugada syndrome, and LQTS are inherited ion channelopathies. CPVT may present as bidirectional VT, polymorphic VT, or catecholaminergic ventricular fibrillation. Syncope and sudden death in Brugada syndrome are usually due to polymorphic VT. The characteristic arrhythmia of LQTS is torsades de pointes. Overall, patients with idiopathic VT have a better prognosis than do patients with ventricular arrhythmias and structural heart disease. Initial treatment approach is pharmacologic and radiofrequency ablation is curative in most patients. However, radiofrequency ablation is not useful in the management of inherited ion channelopathies. Prognosis for patients with VT secondary to ion channelopathies is variable. High-risk patients (recurrent syncope and sudden cardiac death survivors) with inherited ion channelopathies benefit from implantable cardioverter-defibrillator placement. This paper reviews the mechanism, clinical presentation, and management of VT in the absence of structural heart disease

    Sensitivity of IceCube-DeepCore to neutralino dark matter in the MSSM-25

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    We analyse the sensitivity of IceCube-DeepCore to annihilation of neutralino dark matter in the solar core, generated within a 25 parameter version of the minimally supersymmetric standard model (MSSM-25). We explore the 25-dimensional parameter space using scanning methods based on importance sampling and using DarkSUSY 5.0.6 to calculate observables. Our scans produced a database of 6.02 million parameter space points with neutralino dark matter consistent with the relic density implied by WMAP 7-year data, as well as with accelerator searches. We performed a model exclusion analysis upon these points using the expected capabilities of the IceCube-DeepCore Neutrino Telescope. We show that IceCube-DeepCore will be sensitive to a number of models that are not accessible to direct detection experiments such as SIMPLE, COUPP and XENON100, indirect detection using Fermi-LAT observations of dwarf spheroidal galaxies, nor to current LHC searches.Comment: 15 pages, 13 figures. V2: Additional comparisons are made to limits from Fermi-LAT observations of dwarf spheroidal galaxies and to the 125 GeV Higgs signal from the LHC. The spectral hardness section has been removed. Matches version accepted for publication in JCAP. V3: Typos correcte
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